gaboxadol

Modify Date: 2026-06-30 20:01:07

gaboxadol structure	Common Name	gaboxadol
	CAS Number	64603-91-4	Molecular Weight	140.140
	Density	1.3±0.1 g/cm3	Boiling Point	340.5±42.0 °C at 760 mmHg
	Molecular Formula	C₆H₉ClN₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	159.7±27.9 °C

Use of gaboxadol

THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1].

Summary: Gaboxadol (THIP hydrochloride), Chinese name: 盐酸加波沙朵, CAS number: 64603-91-4, molecular formula: C6H9ClN2O2, molecular weight: 140.140. It is a white solid with a boiling point of 340.5±42.0 °C and a density of 1.3±0.1 g/cm3. For research-use only, not for medical or clinical usage.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	α4β3δ GABAAR:13 μM (EC50)
References	[1]. Hoestgaard-Jensen K, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014 Dec 3;34(49):16256-72.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	340.5±42.0 °C at 760 mmHg
Molecular Formula	C₆H₉ClN₂O₂
Molecular Weight	140.140
Flash Point	159.7±27.9 °C
Exact Mass	140.058578
PSA	58.29000
LogP	-0.61
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.551

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY3396800

CHEMICAL NAME :: Isoxazolo(5,4-c)pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrate

CAS REGISTRY NUMBER :: 64603-91-4

LAST UPDATED :: 199103

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H8-N2-O2.H2-O

MOLECULAR WEIGHT :: 158.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 98 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 21,803,1982

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

4,5,6,7-tetrahy...

CAS#:815574-58-4

gaboxadol

CAS#:64603-91-4

Learn More

Literature: US2005/171142 A1, ; Page/Page column 5 ;

methyl 3,4,5,7-...

CAS#:65202-62-2

gaboxadol

CAS#:64603-91-4

Learn More

Literature: US4278676 A1, ;

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 2
CAS#:815574-58-4 4,5,6,7-tetrahy... CAS#:65202-62-2 methyl 3,4,5,7-...
DownStream 0

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Displacement of [3H]muscimol from GABAA receptor in rat brain synaptic membranes
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-3
External Id: CHEMBL864181

Name: Inhibition of [3H]GABA binding in GABAA receptor in rat brain synaptic membranes
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-3
External Id: CHEMBL864182

Name: In vitro effect of Gamma-aminobutyric acid enhancement on single neurons of cat spina...
Source: ChEMBL
Target: Felis catus
External Id: CHEMBL660180

Name: Agonist activity at GABA type-A receptor in human IMR32 cells at 1 mM after 2 hrs by ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3807274

Name: In vitro effect of glycine antagonism on single neurons in the cat spinal cord.; ND m...
Source: ChEMBL
Target: Felis catus
External Id: CHEMBL660184

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Total 319, Current Page 1 of 32

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one

4,5,6,7-tetrahydroisoxazolo<5,4-c>pyridine-3-ol

3-methoxy-4,5,6,7-tetrahydroisoxazole<5,4-c>pyridinium

4,5,6,7-Tetrahydroisoxazolo<5,4-c>-pyridin-3-ol

THIP HYDROCHLORIDE

4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol

4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-3(2H)-one

Gaboxadolum

THPO

4,5,6,7-Tetrahydro[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate

Einecs 264-963-0

Lu 02-030

THIP

gaboxadol

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the uses of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride?

A: Main uses of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride: THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist, functionally selective GABAAR ligand, exhibits agonism at α4β1δ, α4β3δ and weak antagonism at αβγ and α4β2δ GABAARs[1].

Q: What is the polar surface area (PSA) of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride?

A: Polar surface area (PSA) of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride is 58.29000.

Q: What is the LogP of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride?

A: LogP of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride is -0.61.

Q: What is the molecular weight of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride?

A: Molecular weight of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride is 140.140.

Q: What is the CAS number of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride?

A: CAS number of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride is 64603-91-4.

Q: What are the upstream materials of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride?

A: Related upstream materials(CAS) of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride: 815574-58-4;65202-62-2.

Q: What is the boiling point of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride?

A: Boiling point of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride is 340.5±42.0 °C at 760 mmHg.

Q: What is the English name of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride?

A: The English name of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride is THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride.

Q: What is the molecular formula of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride?

A: Molecular formula of THIP hydrochloride,4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride is C6H9ClN2O2.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: THIP
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: THIP hydrochloride;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-olhydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Use of gaboxadol

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.