Prostaglandin E1
Prostaglandin E1 structure
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Common Name | Prostaglandin E1 | ||
|---|---|---|---|---|
| CAS Number | 745-65-3 | Molecular Weight | 354.481 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 529.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H34O5 | Melting Point | 115-116 °C | |
| MSDS | Chinese USA | Flash Point | 288.0±26.6 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
Use of Prostaglandin E1Prostaglandin E1 (PGE1) is a potent vasodilator and activates the prostaglandin E1 (EP) receptor. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | prostaglandin E1 |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Prostaglandin E1 (PGE1) is a potent vasodilator and activates the prostaglandin E1 (EP) receptor. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 529.3±50.0 °C at 760 mmHg |
| Melting Point | 115-116 °C |
| Molecular Formula | C20H34O5 |
| Molecular Weight | 354.481 |
| Flash Point | 288.0±26.6 °C |
| Exact Mass | 354.240631 |
| PSA | 94.83000 |
| LogP | 2.24 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.546 |
| InChIKey | GMVPRGQOIOIIMI-DWKJAMRDSA-N |
| SMILES | CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(=O)O |
| Storage condition | -20℃ |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H361 |
| Precautionary Statements | P281-P301 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22 |
| Safety Phrases | 36-26 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | GY4569800 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 29375000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 3 | |
|---|---|
| DownStream 0 | |
CAS#:3434-33-1
CAS#:125180-13-4![(1S)-1-[(2R)-oxiran-2-yl]prop-2-en-1-ol Structure](https://image.chemsrc.com/caspic/044/100017-22-9.png)
CAS#:100017-22-9This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 29375000 |
|---|
This table lists relevant public references with title, journal and publication metadata for this compound.
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ... |
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LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa.
J. Pharmacol. Sci. 127 , 462-6, (2015) Based on the structure of AAP, a novel anti-thrombotic peptide from snake venom which we discovered in our previous study, more than 60 compounds were designed and synthesized. One of these termed as ... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: pKa (acid-base dissociation constant) as determined by Avdeef ref: DOI: 10.1002/04714...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449007
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
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Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
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Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
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Name: Inhibitory activity against ADP-induced platelet aggregation using human platelet ric...
Source: ChEMBL
Target: Homo sapiens
External Id: CHEMBL700477
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Name: Thermal Shift Assay. Domain: start/stop: P449-E759
Source: ChEMBL
Target: Fibroblast growth factor receptor 3
External Id: CHEMBL5065404
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Name: Thermal Shift Assay. Domain: start/stop: E122-S403
Source: ChEMBL
Target: Aurora kinase A
External Id: CHEMBL5067447
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Name: Stimulation of prostanoid receptor-mediated cAMP accumulation in Charles River CD-1 m...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3281718
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Name: Incucyte cell viability with human fibroblast
Source: ChEMBL
Target: Fibroblast
External Id: CHEMBL4725213
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| EINECS 212-017-2 |
| ProstaglandinE1 |
| Minprog |
| Prostaglandine E |
| PGE1 |
| PegE1 |
| Prostaglandin E1 |
| Topiglan |
| Palux |
| Liple |
| (1R,2R,3R)-3-Hydroxy-2-((E)-(3S)-3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid |
| 7-{(1R,2R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl}heptanoic acid |
| alprostadil |
| (11a,13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid |
| (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid |
| ONO 1608 |
| MFCD00077860 |
| (11a,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid |
| PGEl |
| Caverject |
| l-pge1 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of prostaglandin E1? |
| A: Boiling point of prostaglandin E1 is 529.3±50.0 °C at 760 mmHg. |
| Q: What is the InChIKey of prostaglandin E1? |
| A: InChIKey of prostaglandin E1 is GMVPRGQOIOIIMI-DWKJAMRDSA-N. |
| Q: What is the LogP of prostaglandin E1? |
| A: LogP of prostaglandin E1 is 2.24. |
| Q: What is the CAS number of prostaglandin E1? |
| A: CAS number of prostaglandin E1 is 745-65-3. |
| Q: What is the safety information for prostaglandin E1? |
| A: Safety information for prostaglandin E1: 36-26. |
| Q: What are the uses of prostaglandin E1? |
| A: Main uses of prostaglandin E1: Prostaglandin E1 (PGE1) is a potent vasodilator and activates the prostaglandin E1 (EP) receptor. |
| Q: What is the polar surface area (PSA) of prostaglandin E1? |
| A: Polar surface area (PSA) of prostaglandin E1 is 94.83000. |
| Q: What is the molecular weight of prostaglandin E1? |
| A: Molecular weight of prostaglandin E1 is 354.481. |
| Q: What are the storage conditions for prostaglandin E1? |
| A: Storage conditions for prostaglandin E1: -20℃. |
| Q: What is the English name of prostaglandin E1? |
| A: The English name of prostaglandin E1 is prostaglandin E1. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |