Enalaprilat Dihydrate
Enalaprilat Dihydrate structure
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Common Name | Enalaprilat Dihydrate | ||
|---|---|---|---|---|
| CAS Number | 84680-54-6 | Molecular Weight | 384.424 | |
| Density | N/A | Boiling Point | 563.5ºC at 760 mmHg | |
| Molecular Formula | C18H28N2O7 | Melting Point | 211-215°C | |
| MSDS | Chinese USA | Flash Point | 294.6ºC | |
Use of Enalaprilat DihydrateEnalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.Target: ACEEnalaprilat has high affinity for human endothelial ACE with IC50 of 1.94 nM in vitro binding assay by displacing a saturating concentration of [125I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykinin/angiotensin I selectivity ratio of 1.00 calculated from double displacement experiments [1]. Enalaprilat attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with IC50 of 90 mM [2].Administration of Enalaprilat induces a significant reduction of MAP at 70 minutes compared with the placebo group during haemorrhagic shock in rats, and results in a 50% reduction of CO, a general tendency of EB extravasation which is significant in the kidney and lungs, and a significant increase in ileal EB extravasation (53%) [3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | enalaprilat dihydrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.Target: ACEEnalaprilat has high affinity for human endothelial ACE with IC50 of 1.94 nM in vitro binding assay by displacing a saturating concentration of [125I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykinin/angiotensin I selectivity ratio of 1.00 calculated from double displacement experiments [1]. Enalaprilat attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with IC50 of 90 mM [2].Administration of Enalaprilat induces a significant reduction of MAP at 70 minutes compared with the placebo group during haemorrhagic shock in rats, and results in a 50% reduction of CO, a general tendency of EB extravasation which is significant in the kidney and lungs, and a significant increase in ileal EB extravasation (53%) [3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 563.5ºC at 760 mmHg |
|---|---|
| Melting Point | 211-215°C |
| Molecular Formula | C18H28N2O7 |
| Molecular Weight | 384.424 |
| Flash Point | 294.6ºC |
| Exact Mass | 384.189636 |
| PSA | 125.40000 |
| LogP | 1.32630 |
| Index of Refraction | 1.579 |
| InChIKey | MZYVOFLIPYDBGD-MLZQUWKJSA-N |
| SMILES | CC(NC(CCc1ccccc1)C(=O)O)C(=O)N1CCCC1C(=O)O.O.O |
| Storage condition | -20°C Freezer |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S22-S26-S36/37/39 |
| RIDADR | NONH for all modes of transport |
| RTECS | TW3590600 |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Evaluation of a rapid method for the therapeutic drug monitoring of aliskiren, enalapril and its active metabolite in plasma and urine by UHPLC-MS/MS.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 79-87, (2015) Given the increasing popularity of aliskiren, particularly in combination with angiotensin converting enzyme inhibitor (e.g. enalapril), it is important to determine whether its use in combination wit... |
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Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat.
Drug Metab. Dispos. 42(9) , 1567-74, (2014) Hepatic uptake and efflux transporters govern the systemic and hepatic exposure of many drugs and metabolites. Enalapril is a pharmacologically inactive prodrug of enalaprilat. Following oral administ... |
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Enalaprilat.
Dimens. Crit. Care Nurs. 19(2) , 22, (2000)
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This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: HTS to identify compounds that affect the blood-brain barrier permeability in vitro
Source: 26908
Target: N/A
External Id: HTS97080
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Name: Primary high throughput screening by co-culture imaging for identification hits as a ...
Source: 23209
Target: N/A
External Id: UIHTS20180925
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Name: MELAS cybrid survival enhancement under low glucose conditions
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1419
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Name: Inhibition of cell viability relative to arbidol control (inhibition index > 1 indica...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303819
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| MFCD00941393 |
| ENALAPRILAT DIHYDRATE |
| 2-[N-(1-Carboxy-3-phenylpropyl)alanyl]-1-pyrrolidinecarboxylic acid dihydrate |
| EINECS 278-459-3 |
| 1-Pyrrolidinecarboxylic acid, 2-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-, hydrate (1:2) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does enalaprilat dihydrate have? |
| A: English synonyms of enalaprilat dihydrate: MFCD00941393, ENALAPRILAT DIHYDRATE, 2-[N-(1-Carboxy-3-phenylpropyl)alanyl]-1-pyrrolidinecarboxylic acid dihydrate, EINECS 278-459-3, 1-Pyrrolidinecarboxylic acid, 2-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-, hydrate (1:2). |
| Q: What is the English name of enalaprilat dihydrate? |
| A: The English name of enalaprilat dihydrate is enalaprilat dihydrate. |
| Q: What is the melting point of enalaprilat dihydrate? |
| A: Melting point of enalaprilat dihydrate is 211-215°C. |
| Q: What are the storage conditions for enalaprilat dihydrate? |
| A: Storage conditions for enalaprilat dihydrate: -20°C Freezer. |
| Q: What is the molecular weight of enalaprilat dihydrate? |
| A: Molecular weight of enalaprilat dihydrate is 384.424. |
| Q: What is the safety information for enalaprilat dihydrate? |
| A: Safety information for enalaprilat dihydrate: S22-S26-S36/37/39. |
| Q: What is the CAS number of enalaprilat dihydrate? |
| A: CAS number of enalaprilat dihydrate is 84680-54-6. |
| Q: What is the polar surface area (PSA) of enalaprilat dihydrate? |
| A: Polar surface area (PSA) of enalaprilat dihydrate is 125.40000. |
| Q: What is the SMILES notation of enalaprilat dihydrate? |
| A: SMILES notation of enalaprilat dihydrate is CC(NC(CCc1ccccc1)C(=O)O)C(=O)N1CCCC1C(=O)O.O.O. |
| Q: What is the molecular formula of enalaprilat dihydrate? |
| A: Molecular formula of enalaprilat dihydrate is C18H28N2O7. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |