Orientin

Modify Date: 2025-08-20 21:16:59

Orientin Structure
Orientin structure
Common Name Orientin
CAS Number 28608-75-5 Molecular Weight 448.377
Density 1.8±0.1 g/cm3 Boiling Point 816.1±65.0 °C at 760 mmHg
Molecular Formula C21H20O11 Melting Point 260-285ºC
MSDS Chinese USA Flash Point 289.1±27.8 °C

 Use of Orientin


Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. Orientin is a promising neuroprotective agent suitable for therapy for neuropathic pain[1][2].

 Names

Name Orientine
Synonym More Synonyms

 Orientin Biological Activity

Description Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. Orientin is a promising neuroprotective agent suitable for therapy for neuropathic pain[1][2].
Related Catalog
References

[1]. Dhakal H, et al. Inhibitory effects of orientin in mast cell-mediated allergic inflammation. Pharmacol Rep. 2020 Jan 24.

[2]. Guo D, et al. Orientin and neuropathic pain in rats with spinal nerve ligation. 61Int Immunopharmacol. 2018 May;58:72-79.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 816.1±65.0 °C at 760 mmHg
Melting Point 260-285ºC
Molecular Formula C21H20O11
Molecular Weight 448.377
Flash Point 289.1±27.8 °C
Exact Mass 448.100555
PSA 201.28000
LogP 1.58
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.767
InChIKey PLAPMLGJVGLZOV-VPRICQMDSA-N
SMILES O=c1cc(-c2ccc(O)c(O)c2)oc2c(C3OC(CO)C(O)C(O)C3O)c(O)cc(O)c12
Storage condition 2~8°C
Water Solubility 1 M NaOH: soluble1mg/mL, clear, yellow-orange

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ3009300
CHEMICAL NAME :
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-d ihydroxy-
CAS REGISTRY NUMBER :
28608-75-5
LAST UPDATED :
199106
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H20-O11
MOLECULAR WEIGHT :
448.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25
RIDADR NONH for all modes of transport
RTECS DJ3009300

 Articles25

More Articles
Distinction of the C-glycosylflavone isomer pairs orientin/isoorientin and vitexin/isovitexin using HPLC-MS exact mass measurement and in-source CID.

Phytochem. Anal. 16(5) , 295-301, (2005)

HPLC-MS using collision induced dissociation (CID) has been utilised for the identification of the C-glycosylflavone isomer pairs orientin/isoorientin and vitexin/isovitexin. HPLC-CID/MS analyses prod...

Antihypertensive and cardioprotective effects of the Lagenaria siceraria fruit in NG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats.

Pharm. Biol. 50(11) , 1428-35, (2012)

Lagenaria siceraria (Molina) Standl. (Cucurbitacae) (LS) has been reported to possess cardioprotective, antihyperlipidemic, and diuretic activities.To evaluate antihypertensive and cardioprotective ef...

Development and validation of an HPTLC method for simultaneous quantitation of isoorientin, isovitexin, orientin, and vitexin in bamboo-leaf flavonoids.

J. AOAC Int. 93(5) , 1376-83, (2010)

A simple HPTLC method has been developed for the simultaneous determination of isoorientin, isovitexin, orientin, and vitexin, both pure and in commercial samples of bamboo-leaf flavonoids. The flavon...

 OrientinBioassay

View more

Name: NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C...
Source: NCGC
Target: N/A
External Id: adst_HEK293_Anti-infectives-02
Name: NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay
Source: NCGC
Target: N/A
External Id: adst_Celegans_Anti-infectives-o1
Name: Retention time of the compound by HPLC-SPE-NMR analysis
Source: ChEMBL
Target: N/A
External Id: CHEMBL3599800
Name: Inhibition of LPS-induced neutrophil adhesion in HUVEC cells assessed as neutrophil a...
Source: ChEMBL
Target: HUVEC
External Id: CHEMBL3631152
Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data
Name: Cytotoxicity against human HMC1 cells assessed induction of morphological changes at ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1112532
Name: Inhibition of LPS-induced hyperpermeability in HUVEC cells assessed as permeability a...
Source: ChEMBL
Target: HUVEC
External Id: CHEMBL3631149
Name: Kinase Assay from Article 10.1002/cbic.201000487: "Biological evaluation and structur...
Source: BindingDB
Target: N/A
External Id: BindingDB_5042_1
Name: Inhibition of LPS-induced neutrophil migration in HUVEC cells assessed as migration i...
Source: ChEMBL
Target: HUVEC
External Id: CHEMBL3631155
Name: Cytotoxicity against human KB cells
Source: ChEMBL
Target: KB
External Id: CHEMBL1002689
Total 17, Current Page 1 of 2
1
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 Synonyms

isoorientin
(1S)-1,5-Anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-8-yl]-D-glucitol
2-(3,4-Dihydroxyphényl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]-4H-chromén-4-one
Orientin 8-C-β-D-glucopyranoside
3',4',5,7-tetrahydroxyflavone-8-C-glucoside
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-4H-chromen-4-on
Luteolin-8-C-glucoside
3',4',5,7-tetrahydroxyflavone 8-glucoside
Orientin
lutexin
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-4H-chromen-4-one
2-(3,4-Dihydroxyphenyl)-8-b-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
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