KL-1333(NQO1 activator 1)
Modify Date: 2025-09-03 20:00:41
KL-1333(NQO1 activator 1) structure
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Common Name | KL-1333(NQO1 activator 1) | ||
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| CAS Number | 1800405-30-4 | Molecular Weight | 240.26 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H12N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KL-1333(NQO1 activator 1)NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts[1]. |
| Name | NQO1 activator 1 |
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| Description | NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts[1]. |
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| Related Catalog | |
| Target |
NQO1[1] |
| References |
| Molecular Formula | C14H12N2O2 |
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| Molecular Weight | 240.26 |
| InChIKey | AJFWITSBVLLDCC-UHFFFAOYSA-N |
| SMILES | CC(C)c1nc2c([nH]1)C(=O)C(=O)c1ccccc1-2 |