Bioymifi
Modify Date: 2025-09-25 18:49:54
Bioymifi structure
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Common Name | Bioymifi | ||
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| CAS Number | 1420071-30-2 | Molecular Weight | 494.317 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H12BrN3O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BioymifiBioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.IC50 value:Target: In comparison with A2C2, bioymifi was able to promote cell death without the need for the Smac mimetic in T98G cells. Notably, at a 10-μM concentration, bioymifi induced processing of caspase-3 into smaller fragments. Z-VAD inhibited these caspase-mediated cleavages. caspase-3 was rapidly activated as early as 2 h after bioymifi treatment of T98G cells. The caspase-3 activity was markedly increased after 8 h of treatment. Bioymifi induces caspase-8–dependent apoptosis. |
| Name | 5-(5-{(Z)-[3-(4-Bromophenyl)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)-1H-isoindole-1,3(2H)-dione |
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| Synonym | More Synonyms |
| Description | Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.IC50 value:Target: In comparison with A2C2, bioymifi was able to promote cell death without the need for the Smac mimetic in T98G cells. Notably, at a 10-μM concentration, bioymifi induced processing of caspase-3 into smaller fragments. Z-VAD inhibited these caspase-mediated cleavages. caspase-3 was rapidly activated as early as 2 h after bioymifi treatment of T98G cells. The caspase-3 activity was markedly increased after 8 h of treatment. Bioymifi induces caspase-8–dependent apoptosis. |
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| Related Catalog | |
| References |
| Density | 1.8±0.1 g/cm3 |
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| Molecular Formula | C22H12BrN3O4S |
| Molecular Weight | 494.317 |
| Exact Mass | 492.973175 |
| LogP | 4.80 |
| Appearance of Characters | yellow solid |
| Index of Refraction | 1.791 |
| InChIKey | ULBOWKXOFOTCMU-NLDKGBHCSA-N |
| SMILES | N=C1SC(=Cc2ccc(-c3ccc4c(c3)C(=O)NC4=O)o2)C(=O)N1c1ccc(Br)cc1 |
| Storage condition | -20℃ |
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| 5-(5-{(Z)-[3-(4-Bromophenyl)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)-1H-isoindole-1,3(2H)-dione |
| Bioymifi |