Bioymifi

Names

[ CAS No. ]:
1420071-30-2

[ Name ]:
Bioymifi

[Synonym ]:
1H-Isoindole-1,3(2H)-dione, 5-[5-[(Z)-[3-(4-bromophenyl)-2-imino-4-oxo-5-thiazolidinylidene]methyl]-2-furanyl]-
5-(5-{(Z)-[3-(4-Bromophenyl)-2-imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl}-2-furyl)-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
Bioymifi

Biological Activity

[Description]:

Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells.IC50 value:Target: In comparison with A2C2, bioymifi was able to promote cell death without the need for the Smac mimetic in T98G cells. Notably, at a 10-μM concentration, bioymifi induced processing of caspase-3 into smaller fragments. Z-VAD inhibited these caspase-mediated cleavages. caspase-3 was rapidly activated as early as 2 h after bioymifi treatment of T98G cells. The caspase-3 activity was markedly increased after 8 h of treatment. Bioymifi induces caspase-8–dependent apoptosis.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> TNF Receptor

Research Areas >> Cancer

[References]

[1]. Wang G, et al. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nat Chem Biol. 2013 Feb;9(2):84-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Molecular Formula ]:
C₂₂H₁₂BrN₃O₄S

[ Molecular Weight ]:
494.317

[ Exact Mass ]:
492.973175

[ LogP ]:
4.80

[ Appearance of Characters ]:
yellow solid

[ Index of Refraction ]:
1.791

[ Storage condition ]:
-20℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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