MSA-2

Published date: 2022-11-29 15:44:27
MSA-2 Structure
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Name MSA 2 CAS# 129425-81-6
Price ￥Inquiry/1g Purity 98.9%
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Period		 1 Day Stock In Stock
 Detail Product Information
MSA-2 is an orally available human STING agonist.MSA-2 is bound to STING as a noncovalent dimer. Extensive experimental analysis indicates that MSA-2 predimerization is required for binding. Acidic tumor microenvironments favor permeable, uncharged MSA-2. Intracellular MSA-2 is "trapped" and accumulation drives MSA-2 dimerization, preferentially activating STING intratumorally. Orally dosed MSA-2 is well tolerated in mice, exhibiting STING-dependent antitumor activity, as monotherapy and combined with antibodies against PD1 (anti-PD1).
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2024-07-15 MSA 2
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2020-08-27 MSA-2
Price: $700.0
2021-04-03 MSA-2
Price: ￥2890.0
2023-11-18 MSA-2
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