MSA 2
Modify Date: 2024-01-02 18:14:34
MSA 2 structure
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Common Name | MSA 2 | ||
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| CAS Number | 129425-81-6 | Molecular Weight | 294.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H14O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MSA 2MSA-2 is an orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1]. |
| Name | MSA-2 |
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| Synonym | More Synonyms |
| Description | MSA-2 is an orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 shows antitumor activity and stimulates interferon-β secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1]. |
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| Related Catalog | |
| In Vivo | MSA-2 dosed via either PO or SC regimens achieved comparable exposure in both tumor and plasma. MSA-2 also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes, and dosing regimens were identified that induced complete tumor regressions in 80 to 100% of treated animals[1]. MSA-2 (PO: 60 mg/kg or SC: 50 mg/kg; single dose) that effectively inhibits tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor[1]. Animal Model: MC38 tumor-bearing C57BL6 mice[1] Dosage: 60 mg/kg Administration: P.o. ; s.c (50 mg/kg); single dose Result: PO or SC doses of MSA-2 that effectively inhibited tumor growth induced substantial elevations of IFN-β, interleukin-6 (IL-6), and TNF-α in tumor. |
| References |
| Molecular Formula | C14H14O5S |
|---|---|
| Molecular Weight | 294.32 |
| Storage condition | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| 5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid |