RET agonist BT44
Published date: 2022-06-22 21:57:40
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Name | RET agonist BT44 | CAS# | 924759-42-2 |
|---|---|---|---|---|
| Price | $800.0/100mg $1450.0/250mg $2900.0/1g $220.0/10ml | Purity | 98.0% | |
| Stocking Period |
3 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-retagonistbt44.html | |||
| Detail
Product Information
RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain. |
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