924759-42-2
924759-42-2 structure
- Name: RET agonist BT44
- Chemical Name: RET agonist BT44
- CAS Number: 924759-42-2
- Molecular Formula: C28H27F4N3O4S
- Molecular Weight: 577.595
- Catalog: Research Areas Neurological Disease
- Create Date: 2022-06-28 17:57:42
- Modify Date: 2025-09-20 17:22:18
-
RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain.
| Name | RET agonist BT44 |
|---|
| Description | RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain. |
|---|---|
| References | 1. Viisanen H, et al. Mol Pain. 2020 Jan-Dec;16:1744806920950866. 2. Renko JM, et al. J Parkinsons Dis. 2021;11(3):1023-1046. |
| Molecular Formula | C28H27F4N3O4S |
|---|---|
| Molecular Weight | 577.595 |