HPPE
Published date: 2022-06-22 21:57:40
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Name | HPPE | CAS# | 1325721-55-8 |
|---|---|---|---|---|
| Price | $1080.0/100mg | Purity | 98.0% | |
| Stocking Period |
3 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-hppe.html | |||
| Detail
Product Information
HPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression.HPPE induces up-regulation of Hmox1 mRNA is mediated by Bach1 inhibition in vivo.Nuclear export of Bach1 is required for HPPE-mediated Bach1 derepression, HPPE has an additional activity in Nrf2 stabilization besides Bach1 inhibition.Pre- and posttreatment of HPPE is neuroprotective against acute MPTP neurotoxicity.HPPE significantly reduced MPTP-induced increases in TNF-α and Mcp-1 mRNA levels, HPPE significantly increased mRNA levels of Nrf2 compared to MPTP-treated mice that received the vehicle.Bach1 is a known transcriptional repressor of the Nrf2 pathway.Bach1 ablation is cytoprotective, as it suppresses reactive oxygen species (ROS) generation, mitigates excessive inflammation, improves mitochondrial function, and inhibits apoptosis. |
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