1325721-55-8
1325721-55-8 structure
- Name: HPPE
- Chemical Name: HPPE
- CAS Number: 1325721-55-8
- Molecular Formula: C21H20F3N5O3S
- Molecular Weight: 479.478
- Catalog: Research Areas Metabolic Disease
- Create Date: 2022-07-01 17:48:36
- Modify Date: 2024-01-08 18:03:50
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HPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression.HPPE induces up-regulation of Hmox1 mRNA is mediated by Bach1 inhibition in vivo.Nuclear export of Bach1 is required for HPPE-mediated Bach1 derepression, HPPE has an additional activity in Nrf2 stabilization besides Bach1 inhibition.Pre- and posttreatment of HPPE is neuroprotective against acute MPTP neurotoxicity.HPPE significantly reduced MPTP-induced increases in TNF-α and Mcp-1 mRNA levels, HPPE significantly increased mRNA levels of Nrf2 compared to MPTP-treated mice that received the vehicle.Bach1 is a known transcriptional repressor of the Nrf2 pathway.Bach1 ablation is cytoprotective, as it suppresses reactive oxygen species (ROS) generation, mitigates excessive inflammation, improves mitochondrial function, and inhibits apoptosis.
| Name | HPPE |
|---|
| Description | HPPE is a specific nonelectrophilic and physiological Bach1 inhibitor via heme-binding sites of Bach1 protein, derepresses Bach1-mediated repression.HPPE induces up-regulation of Hmox1 mRNA is mediated by Bach1 inhibition in vivo.Nuclear export of Bach1 is required for HPPE-mediated Bach1 derepression, HPPE has an additional activity in Nrf2 stabilization besides Bach1 inhibition.Pre- and posttreatment of HPPE is neuroprotective against acute MPTP neurotoxicity.HPPE significantly reduced MPTP-induced increases in TNF-α and Mcp-1 mRNA levels, HPPE significantly increased mRNA levels of Nrf2 compared to MPTP-treated mice that received the vehicle.Bach1 is a known transcriptional repressor of the Nrf2 pathway.Bach1 ablation is cytoprotective, as it suppresses reactive oxygen species (ROS) generation, mitigates excessive inflammation, improves mitochondrial function, and inhibits apoptosis. |
|---|---|
| References | 1. Manuj Ahuja, et al. Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):e2111643118. |
| Molecular Formula | C21H20F3N5O3S |
|---|---|
| Molecular Weight | 479.478 |