BT-2
Published date: 2021-12-17 15:49:26
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Name | 3,6-Dichloro-1-benzothiophene-2-carboxylic acid | CAS# | 34576-94-8 |
|---|---|---|---|---|
| Price | ￥650.0/100mg ￥1100.0/250mg ￥2200.0/1g | Purity | 98.0% | |
| Stocking Period |
1 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-34576-94-8.html | |||
| Detail
Product Information
BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC)[1]. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM[2]. |
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