Emavusertib(CA-4948)
Published date: 2021-03-17 16:23:12
|
Name | CA-4948 | CAS# | 1801344-14-8 |
|---|---|---|---|---|
| Price | $990.0/100mg ￥1800.0/250mg ￥3600.0/1g | Purity | 98.0% | |
| Stocking Period |
1 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-1801344-14-8.html | |||
| Detail
Product Information
CA-4948 is a potent IRAK4/FLT3 inhibtor with anti-tumor activity[1].CA-4948 is over 500-fold more selective for IRAK-4 compared to IRAK-1. CA-4948 reduces TNF-α, IL-1β, IL-6 and IL-8 release from TLR-Stimulated THP-1 Cells with an IC50 <250 nM. CA-4948 also has antiproliferative activity due to inhibition of receptor-type tyrosine-protein kinase FLT3[1].CA-4948 shows anti-tumor activity in animal models including tumors containing MyD88 gene mutations. CA-4948 shows antileukemic activity in mouse models of FLT3 wild-type and FLT3 mutated acute myeloid leukemia (AML)[1]. |
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