Cytosporone B
Published date: 2020-07-06 12:20:55
|
Name | Cytosporone B | CAS# | 321661-62-5 |
|---|---|---|---|---|
| Price | $550.0/100mg $950.0/250mg $1900.0/1g | Purity | 98.0% | |
| Stocking Period |
1 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-Cytosporone_B.html | |||
| Detail
Product Information
Cytosporone B is the first naturally occurring agonist for nuclear orphan receptor Nur77. The molecule binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is also involved in glucose homeostasis, where it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth. |
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