Chlorpheniramine maleate
Modify Date: 2026-06-30 15:42:54
Chlorpheniramine maleate structure
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Common Name | Chlorpheniramine maleate | ||
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| CAS Number | 113-92-8 | Molecular Weight | 390.861 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 379.0±42.0 °C at 760 mmHg | |
| Molecular Formula | C20H23ClN2O4 | Melting Point | 130-135 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 183.0±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Chlorpheniramine maleateChlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM.Target: Histamine H1 ReceptorChlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM [1]. Chlorpheniramine displaces of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells with IC50 of 66 nM. Chlorpheniramine displays antimalarial activity against CQS strain (D6) and MDR strain (Dd2) of P. falciparum with IC50 of 61.2 uM and 3.9 uM, respectively. Chlorpheniramine displays cytotoxicity against the proliferation of concanavalin A-induced murine splenic lymphocytes with IC50 of 33.4 μM [2].Oral administration of Chlorpheniramine inhibits histamine-induced mortality in guinea pigs with an ED50 of 0.17 mg/kg [3]. Oral administration of Chlorpheniramine (10 mg/kg) significantly inhibits short-duration scratching in BALB/c mice stimulated by ovalbumin active cutaneous anaphylaxis and in ICR mice subcutaneously injected with histamine, but not long-duration scratching seen in NC/Nga mice, in contrast to that of dexamethasone or tacrolimus [4]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Chlorpheniramine maleate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM.Target: Histamine H1 ReceptorChlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM [1]. Chlorpheniramine displaces of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells with IC50 of 66 nM. Chlorpheniramine displays antimalarial activity against CQS strain (D6) and MDR strain (Dd2) of P. falciparum with IC50 of 61.2 uM and 3.9 uM, respectively. Chlorpheniramine displays cytotoxicity against the proliferation of concanavalin A-induced murine splenic lymphocytes with IC50 of 33.4 μM [2].Oral administration of Chlorpheniramine inhibits histamine-induced mortality in guinea pigs with an ED50 of 0.17 mg/kg [3]. Oral administration of Chlorpheniramine (10 mg/kg) significantly inhibits short-duration scratching in BALB/c mice stimulated by ovalbumin active cutaneous anaphylaxis and in ICR mice subcutaneously injected with histamine, but not long-duration scratching seen in NC/Nga mice, in contrast to that of dexamethasone or tacrolimus [4]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 379.0±42.0 °C at 760 mmHg |
| Melting Point | 130-135 °C(lit.) |
| Molecular Formula | C20H23ClN2O4 |
| Molecular Weight | 390.861 |
| Flash Point | 183.0±27.9 °C |
| Exact Mass | 390.134644 |
| PSA | 90.73000 |
| LogP | 3.39 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.565 |
| InChIKey | DBAKFASWICGISY-UHFFFAOYSA-N |
| SMILES | CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)C=CC(=O)O |
| Storage condition | -20°C Freezer |
| Water Solubility | 1-5 G/100 ML AT 21 ºC |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R25 |
| Safety Phrases | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | US6504000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933399090 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
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| DownStream 2 | |
CAS#:2438-32-6
CAS#:23095-76-3This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Evaluation of Chlorpheniramine Maleate microparticles in orally disintegrating film and orally disintegrating tablet for pediatrics.
Drug Dev. Ind. Pharm. 40(7) , 910-8, (2014) To mask the bitterness of Chlorpheniramine Maleate via encapsulating drug into Eudragit EPO microparticles, and then incorporate these microparticles into orally disintegrating films (ODF) and orally ... |
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Magnetic solid phase extraction coupled with desorption corona beam ionization-mass spectrometry for rapid analysis of antidepressants in human body fluids.
Analyst 140 , 5662-70, (2015) Ambient ionization techniques show good potential in rapid analysis of target compounds. However, a direct application of these ambient ionization techniques for the determination of analytes in a com... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL4296184
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Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186
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Name: Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL4296185
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Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Sedative-hypnotic activity in Swiss Albino mouse assessed as CNS depression at 5 mg/k...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1020376
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Name: Sedative-hypnotic activity in Swiss Albino mouse assessed as CNS depression at 5 mg/k...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1020377
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| teldrin |
| CHLORPHENAMINE MALEATES |
| BISACODYL |
| Chlorphenamine Maleate |
| 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine |
| 2-[p-Chloro-a-(2-dimethylaminoethyl)benzyl]pyridine |
| CHLOROPHENAMINEMALEATE |
| CHLORPHENIRAMINE-D4 MALEATE |
| ChlorpheniramineMaleate |
| alunex |
| Cloropiril |
| M.P. chlorcaps T.D. |
| Chlorpheniramine (maleate) |
| Haynon |
| 3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1) |
| CHLORPHENAMINE HYDROGEN MALEATE, WHO STANDARD |
| EINECS 205-054-0 |
| (±)-Chlorpheniramine maleate |
| UNII:V1Q0O9OJ9Z |
| Allergisan |
| (±)-Chlorpheniramine |
| 3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine |
| Chlortrimeton |
| 2-pyridinepropanamine, g-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) |
| 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine |
| piriex |
| Chloropheniramine maleate |
| piriton |
| P-CHLORO(2-DIMETHYLAMINOETHYL)BENZYLPYRIDINE MALEATE |
| d-chlorpheniramine maleate |
| D-2-(p-Chloro-α-(2-dimethylaminoethyl)benzyl)pyridine |
| (+/-)-CHLORPHENIRAMINE MALEATE SALT |
| dl-Chlorpheniramine |
| chlorpheniramine |
| (+/-)-CHLORPHENIRAMINE-D6 MALEATE |
| CHLORPHENIRAMINE HYDROGEN MALEATE |
| ibioton |
| 2-Pyridinepropanamine |
| Histadur |
| c-meton |
| 4-Chloropheniramine |
| Puermin |
| [3-(4-chlorophenyl)-3-(2-pyridyl)propyl]dimethylamine |
| MFCD00069225 |
| 3-(4-Chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1) |
| 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1) |
| chlorphenamine |
| Cloropiril M.P. |
| CHLORPHENIRAMINE MALEATE REFERENCE STANDARD |
| dexchlorpheniramine maleate |
| 1-(N,N-Dimethylamino)-3-(p-chlorophenyl-3-a-pyridyl)propane Maleate |
| CHLORPROPHENPYRIDAMINE MALEATE |
| g-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine |
| Chlorpheniramine Maleate |
| lorphen |
| Chlorpheniramine Maleate Salt |
| Chlorcaps T.D. |
| allergin |
| g-(4-Chlorophenyl)-g-(2-pyridyl)propyldimethylamine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the downstream products of Chlorpheniramine maleate? |
| A: Related downstream products(CAS) of Chlorpheniramine maleate: 2438-32-6;23095-76-3. |
| Q: What is the melting point of Chlorpheniramine maleate? |
| A: Melting point of Chlorpheniramine maleate is 130-135 °C(lit.). |
| Q: How is the water solubility of Chlorpheniramine maleate? |
| A: Water solubility of Chlorpheniramine maleate: 1-5 G/100 ML AT 21 ºC. |
| Q: What is the English name of Chlorpheniramine maleate? |
| A: The English name of Chlorpheniramine maleate is Chlorpheniramine maleate. |
| Q: What is the boiling point of Chlorpheniramine maleate? |
| A: Boiling point of Chlorpheniramine maleate is 379.0±42.0 °C at 760 mmHg. |
| Q: What is the molecular formula of Chlorpheniramine maleate? |
| A: Molecular formula of Chlorpheniramine maleate is C20H23ClN2O4. |
| Q: What is the InChIKey of Chlorpheniramine maleate? |
| A: InChIKey of Chlorpheniramine maleate is DBAKFASWICGISY-UHFFFAOYSA-N. |
| Q: What is the molecular weight of Chlorpheniramine maleate? |
| A: Molecular weight of Chlorpheniramine maleate is 390.861. |
| Q: What is the CAS number of Chlorpheniramine maleate? |
| A: CAS number of Chlorpheniramine maleate is 113-92-8. |
| Q: What is the polar surface area (PSA) of Chlorpheniramine maleate? |
| A: Polar surface area (PSA) of Chlorpheniramine maleate is 90.73000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |