Harringtonine
Harringtonine structure
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Common Name | Harringtonine | ||
|---|---|---|---|---|
| CAS Number | 26833-85-2 | Molecular Weight | 531.595 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 679.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C28H37NO9 | Melting Point | 73-75ºC | |
| MSDS | N/A | Flash Point | 364.7±31.5 °C | |
Use of HarringtonineHarringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Harringtonin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. |
|---|---|
| Related Catalog | |
| In Vitro | Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation[1]. Harringtonine displays potent inhibition of Chikungunya virus infection with an EC50 of 0.24 μM. Harringtonine could inhibit other alphaviruses[2]. Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations. The mechanism of the antitumor action of harringtonine is considered to be an effect on protein synthesis and is characterized by breakdown of polysomes to monosomes[3]. |
| Cell Assay | For harringtonine treatment studies with Sindbis virus, BHK21 cells are seeded into 96-well plates and infected with Sindbis virus at an MOI of 1 for 1 h prior to being washed twice with PBS and incubated with various concentrations of harringtonine (0.1 μM, 1 μM, 5 μM, and 10 μM) at 37°C with 5% CO2. Cell supernatants are harvested for plaque assays at 24 h postinfection[2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 679.4±55.0 °C at 760 mmHg |
| Melting Point | 73-75ºC |
| Molecular Formula | C28H37NO9 |
| Molecular Weight | 531.595 |
| Flash Point | 364.7±31.5 °C |
| Exact Mass | 531.246826 |
| PSA | 123.99000 |
| LogP | 2.58 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.610 |
| InChIKey | HAVJATCHLFRDHY-KSZYUSJVSA-N |
| SMILES | COC(=O)CC(O)(CCC(C)(C)O)C(=O)OC1C(OC)=CC23CCCN2CCc2cc4c(cc2C13)OCO4 |
| Storage condition | -20℃ |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|---|
| RIDADR | UN 1544 |
| Packaging Group | II |
| Hazard Class | 6.1(a) |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 3 | |
|---|---|
| DownStream 0 | |
CAS#:68423-50-7![(Ξ)-4-benzyloxy-7,7-dimethyl-2-oxo-oxepane-4-carboxylic acid (3aR)-2-methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepin-1t-yl ester Structure](https://image.chemsrc.com/caspic/105/68423-51-8.png)
CAS#:68423-51-8
CAS#:24316-19-6This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| harringtonine |
| O-[(2R)-2,5-Dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methylhexanoyl]cephalotaxine |
| Harringtonine (8CI) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the upstream materials of Harringtonin? |
| A: Related upstream materials(CAS) of Harringtonin: 68423-50-7;68423-51-8;24316-19-6. |
| Q: What is the polar surface area (PSA) of Harringtonin? |
| A: Polar surface area (PSA) of Harringtonin is 123.99000. |
| Q: What is the CAS number of Harringtonin? |
| A: CAS number of Harringtonin is 26833-85-2. |
| Q: What is the molecular formula of Harringtonin? |
| A: Molecular formula of Harringtonin is C28H37NO9. |
| Q: What is the LogP of Harringtonin? |
| A: LogP of Harringtonin is 2.58. |
| Q: What is the English name of Harringtonin? |
| A: The English name of Harringtonin is Harringtonin. |
| Q: What is the InChIKey of Harringtonin? |
| A: InChIKey of Harringtonin is HAVJATCHLFRDHY-KSZYUSJVSA-N. |
| Q: What is the boiling point of Harringtonin? |
| A: Boiling point of Harringtonin is 679.4±55.0 °C at 760 mmHg. |
| Q: What is the melting point of Harringtonin? |
| A: Melting point of Harringtonin is 73-75ºC. |
| Q: What is the molecular weight of Harringtonin? |
| A: Molecular weight of Harringtonin is 531.595. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |