Harringtonine
Names
[ CAS No. ]:
26833-85-2
[ Name ]:
Harringtonine
[Synonym ]:
harringtonine
O-[(2R)-2,5-Dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methylhexanoyl]cephalotaxine
Cephalotaxine, O-[(2R)-2,5-dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methyl-1-oxohexyl]-
Harringtonine (8CI)
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[Cell Assay]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
679.4±55.0 °C at 760 mmHg
[ Melting Point ]:
73-75ºC
[ Molecular Formula ]:
C28H37NO9
[ Molecular Weight ]:
531.595
[ Flash Point ]:
364.7±31.5 °C
[ Exact Mass ]:
531.246826
[ PSA ]:
123.99000
[ LogP ]:
2.58
[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C
[ Index of Refraction ]:
1.610
[ Storage condition ]:
-20℃
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FK0250000
- CHEMICAL NAME :
- Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester), (3(R))-
- CAS REGISTRY NUMBER :
- 26833-85-2
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C28-H37-N-O9
- MOLECULAR WEIGHT :
- 531.66
- WISWESSER LINE NOTATION :
- T5 H5 F675 1A T AX IO KO QN BU JHT&&TTJ CO1 DOVXQ1VQ2XQ1&1 T1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4170 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4200 ug/kg/5D-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Blood - leukopenia Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5200 ug/kg/5D-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Blood - leukopenia Related to Chronic Data - death
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 200 ug/L
- REFERENCE :
- CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,173,1986
Safety Information
[ Hazard Codes ]:
Xi
[ RIDADR ]:
UN 1544
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)