Stachydrine Hydrochloride
Modify Date: 2025-08-22 10:06:10
Stachydrine Hydrochloride structure
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Common Name | Stachydrine Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 4136-37-2 | Molecular Weight | 179.645 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C7H14ClNO2 | Melting Point | 225ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of Stachydrine HydrochlorideStachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases[2]. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities[1]. |
| Name | Stachydrine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases[2]. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities[1]. |
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| Related Catalog | |
| Target |
p65 |
| In Vitro | Intervention of Stachydrine significantly suppresses the level of p-IκB (ser32) protein in the cytosol and NF-κB (p65) protein in the nucleus (P<0.05)[1]. Treatment with Stachydrine hydrochloride (50 µM, 200 µM, 500 µM and 1000 µM) noticeably inhibited MCF-7 and T47D cell proliferation in dose- and time-dependent manner. High concentrations (500 µM and 1000 µM) of Stachydrine significantly increased the frequency of both studied cell lines at the G1 phase of cell cycle, suggesting that Stachydrine hydrochloride could cause cell cycle arrest[2]. |
| Cell Assay | Cell Proliferation Assay[2] Cell Cycle Analysis[2] MCF-7 and T47D cells 50 µM, 200 µM, 500 µM and 1000 µM 24 and 48 hours CCK-8 cell counting assay is used to detect proliferation of MCF-7 and T47D cells when treated with Stachydrine hydrochloride at four different concentrations (50 µM, 200 µM, 500 µM and 1000 µM) for 24 and 48 hours. Cell cycle analysis of MCF-7 and T47D cells is determined by flow cytometry. Experiments are performed in triplicates and representative images are presented. Note: Inhibited proliferation and induced G1 phase arrest in MCF-7 and T47D cells. [1] Guo W, et al. Effect of Leonurus Stachydrine on myocardial cell hypertrophy. Zhong Yao Cai. 2012 Jun;35(6):940-3.https://www.ncbi.nlm.nih.gov/pubmed/23236831[2] Am J Transl Res. 2017 Apr 15;9(4):1834-1844. eCollection 2017.Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways.Wang M1, Shu ZJ1, Wang Y1, Peng W1https://www.ncbi.nlm.nih.gov/pubmed/28469788 |
| References |
| Melting Point | 225ºC |
|---|---|
| Molecular Formula | C7H14ClNO2 |
| Molecular Weight | 179.645 |
| Exact Mass | 179.071304 |
| PSA | 40.13000 |
| InChIKey | DUNMULOWUUIQIL-RGMNGODLSA-N |
| SMILES | C[N+]1(C)CCCC1C(=O)[O-].Cl |
|
~90%
Stachydrine Hyd... CAS#:4136-37-2 |
| Literature: Woster; Murray Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 865 - 868 |
| Precursor 2 | |
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| DownStream 0 | |
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Name: Inhibition of electric eel AChE at 2 mg/ml by Ellman's method
Source: ChEMBL
Target: Acetylcholinesterase
External Id: CHEMBL2166270
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Name: Affinity of compound towards the carnitine/acylcarnitine translocase was determined b...
Source: ChEMBL
Target: Mitochondrial carnitine/acylcarnitine carrier protein
External Id: CHEMBL662624
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Name: Inhibition of horse BChE at 2 mg/ml by Ellman's method
Source: ChEMBL
Target: Cholinesterase
External Id: CHEMBL2166271
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Name: Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: ORF 73 [Human herpesvirus 8 type M]
External Id: HMS791
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Name: Affinity of compound towards the carnitine/acylcarnitine translocase was determined b...
Source: ChEMBL
Target: Mitochondrial carnitine/acylcarnitine carrier protein
External Id: CHEMBL657742
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Name: Affinity of compound towards the carnitine/acylcarnitine translocase was determined b...
Source: ChEMBL
Target: Mitochondrial carnitine/acylcarnitine carrier protein
External Id: CHEMBL657743
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Name: Inhibition of COX2 at 100 uM by scintillation proximity assay
Source: ChEMBL
Target: Prostaglandin G/H synthase 2
External Id: CHEMBL1014033
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Name: Contractile Force Screening of Prestwick Library for asthma drug discovery
Source: 24015
Target: N/A
External Id: HSPH_Screening_CFS_001
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Name: A screen for compounds that inhibit viral RNA polymerase binding and polymerization a...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Chain A, Poliovirus Polymerase With Gtp
External Id: HMS750
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| EINECS 223-957-8 |
| (2S)-1,1-Dimethylpyrrolidinium-2-carboxylate hydrochloride (1:1) |
| stachydrine HCl |
| pyrrolidinium, 2-carboxy-1,1-dimethyl-, chloride, (2S)- (1:1) |
| MFCD00060174 |
| (2S)-1,1-Dimethyl-2-pyrrolidiniumcarboxylathydrochlorid |
| Pyrrolidinium, 2-carboxy-1,1-dimethyl-, inner salt, (2S)-, hydrochloride (1:1) |
| 1,1-Dimethyl-2-pyrrolidiniumcarboxylate hydrochloride (1:1) |
| (2S)-1,1-Diméthyl-2-pyrrolidiniumcarboxylate chlorhydrate |
| (2S)-1,1-Dimethyl-2-pyrrolidiniumcarboxylate hydrochloride (1:1) |
| (2S)-1,1-Dimethyl-2-pyrrolidiniumcarboxylate hydrochloride |
| (2S)-2-Carboxy-1,1-dimethylpyrrolidinium chloride |
| stachydrine hydrochloride |
| Pyrrolidinium, 2-carboxy-1,1-dimethyl-, inner salt, hydrochloride (1:1) |
| UNII:19Z024IC5E |