Clodronic Acid

Modify Date: 2025-08-25 18:42:09

Clodronic Acid Structure
Clodronic Acid structure
 Common Name Clodronic Acid
CAS Number 10596-23-3 Molecular Weight 244.892
Density 2.3±0.1 g/cm3 Boiling Point 474.7±55.0 °C at 760 mmHg
Molecular Formula CH4Cl2O6P2 Melting Point 249-251°
MSDS N/A Flash Point 240.9±31.5 °C

 Use of Clodronic Acid


Clodronic acid is an orally active bisphosphonate, which is used for researching osteoporosis and diseases associated with excessive bone resorption. Clodronic acid inhibits bone resorption through induction of osteoclast apoptosis. Clodronic acid is effective in the maintenance or improvement of bone mineral density[1].

 Names

Name clodronic acid
Synonym More Synonyms

 Clodronic Acid Biological Activity

Description Clodronic acid is an orally active bisphosphonate, which is used for researching osteoporosis and diseases associated with excessive bone resorption. Clodronic acid inhibits bone resorption through induction of osteoclast apoptosis. Clodronic acid is effective in the maintenance or improvement of bone mineral density[1].
Related Catalog
References

[1]. Frediani B, et al. Clodronic acid formulations available in Europe and their use in osteoporosis: a review. Clin Drug Investig. 2009;29(6):359-79.

 Chemical & Physical Properties

Density 2.3±0.1 g/cm3
Boiling Point 474.7±55.0 °C at 760 mmHg
Melting Point 249-251°
Molecular Formula CH4Cl2O6P2
Molecular Weight 244.892
Flash Point 240.9±31.5 °C
Exact Mass 243.886017
PSA 134.68000
LogP -2.38
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.598
InChIKey ACSIXWWBWUQEHA-UHFFFAOYSA-N
SMILES O=P(O)(O)C(Cl)(Cl)P(=O)(O)O

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ7640500
CHEMICAL NAME :
Phosphonic acid, (dichloromethylene)bis-
CAS REGISTRY NUMBER :
10596-23-3
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C-H4-Cl2-O6-P2
MOLECULAR WEIGHT :
244.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg/4D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in iron
REFERENCE :
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 15,365,1987

 Safety Information

HS Code 2931900090

 Customs

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

 Clodronic AcidBioassay

View more

Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291800
Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
Name: Tested for percentage inhibition of PTH stimulated bone resorption in neonatal mouse ...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL719211
Name: Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291792
Name: Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas...
Source: ChEMBL
Target: Prothrombin
External Id: CHEMBL5291794
Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
Name: 1-Octanol/phosphate buffer partition coefficient, logP of the compound at pH 7.4 incu...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5224261
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
Name: Binding affinity towards human DRD1 in an in vitro assay with cellular components (NI...
Source: ChEMBL
Target: D(1A) dopamine receptor
External Id: CHEMBL5291779
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 Synonyms

Clodronic Acid
methanedichlorodiphosphonic acid
Acide clodronique
Acidum clodronicum
Bonefos
Acido clodronico
Clodronsaeure
Dichloromethylidene diphosphonate
(dichloromethylene)bisphosphonic acid
[dichloro(phosphono)methyl]phosphonic acid
Dichloromethanediphosphonic acid
EINECS 234-212-1
dichloromethanediphosphonate
dichloro-methylene diphosphonate
(dichloromethanediyl)bis(phosphonic acid)
(Dichloromethylene)bis(phosphonic acid)
P,P'-(Dichloromethylene)Bis-Phosphonic Acid
Clodronate
dichloromethylenediphosphonic acid
Clodronate disodium
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