Clodronic Acid

Names

[ Name ]:
Clodronic Acid

[Synonym ]:
Clodronic Acid
methanedichlorodiphosphonic acid
Acide clodronique
Acidum clodronicum
Bonefos
Acido clodronico
Clodronsaeure
Dichloromethylidene diphosphonate
(dichloromethylene)bisphosphonic acid
[dichloro(phosphono)methyl]phosphonic acid
Dichloromethanediphosphonic acid
EINECS 234-212-1
dichloromethanediphosphonate
dichloro-methylene diphosphonate
(dichloromethanediyl)bis(phosphonic acid)
(Dichloromethylene)bis(phosphonic acid)
Phosphonic acid, (dichloromethylene)bis-
P,P'-(Dichloromethylene)Bis-Phosphonic Acid
Clodronate
dichloromethylenediphosphonic acid
Clodronate disodium

Biological Activity

[Description]:

Clodronic acid is an orally active bisphosphonate, which is used for researching osteoporosis and diseases associated with excessive bone resorption. Clodronic acid inhibits bone resorption through induction of osteoclast apoptosis. Clodronic acid is effective in the maintenance or improvement of bone mineral density[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Frediani B, et al. Clodronic acid formulations available in Europe and their use in osteoporosis: a review. Clin Drug Investig. 2009;29(6):359-79.

Chemical & Physical Properties

[ Density]:
2.3±0.1 g/cm3

[ Boiling Point ]:
474.7±55.0 °C at 760 mmHg

[ Melting Point ]:
249-251°

[ Molecular Formula ]:
CH₄Cl₂O₆P₂

[ Molecular Weight ]:
244.892

[ Flash Point ]:
240.9±31.5 °C

[ Exact Mass ]:
243.886017

[ PSA ]:
134.68000

[ LogP ]:
-2.38

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.598

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ7640500

CHEMICAL NAME :: Phosphonic acid, (dichloromethylene)bis-

CAS REGISTRY NUMBER :: 10596-23-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C-H4-Cl2-O6-P2

MOLECULAR WEIGHT :: 244.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg/4D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in iron

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 15,365,1987

Safety Information

[ HS Code ]:
2931900090

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%