(E/Z)-Polydatin

Modify Date: 2025-08-21 14:42:57

(E/Z)-Polydatin Structure
(E/Z)-Polydatin structure
Common Name (E/Z)-Polydatin
CAS Number 65914-17-2 Molecular Weight 407.39100
Density 1.521 g/cm3 Boiling Point 707.7ºC at 760 mmHg
Molecular Formula C20H22O8 Melting Point 223-226 °C(lit.)
MSDS USA Flash Point 381.8ºC

 Use of (E/Z)-Polydatin


(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions[1].

 Names

Name (2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Synonym More Synonyms

 (E/Z)-Polydatin Biological Activity

Description (E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions[1].
Related Catalog
References

[1]. Du QH, et al. Polydatin: a review of pharmacology and pharmacokinetics. Pharm Biol. 2013 Nov;51(11):1347-54.

 Chemical & Physical Properties

Density 1.521 g/cm3
Boiling Point 707.7ºC at 760 mmHg
Melting Point 223-226 °C(lit.)
Molecular Formula C20H22O8
Molecular Weight 407.39100
Flash Point 381.8ºC
Exact Mass 407.13400
PSA 160.07000
LogP 0.49640

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles30

More Articles
Protective effect of polydatin against burn-induced lung injury in rats.

Respir. Care 59(9) , 1412-21, (2014)

Polydatin (PD) has anti-inflammatory and anti-apoptotic effects in ischemic-reperfusion injury. Moreover, inflammatory responses and apoptosis play a role in the development of burn-induced lung injur...

Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway.

Oxid. Med. Cell. Longev. 2015 , 362158, (2015)

Oxidative stress and inflammation are involved in the pathogenesis in renal ischemia/reperfusion (I/R) injury. It has been demonstrated that polydatin processed the antioxidative, anti-inflammatory, a...

Pre-column incubation followed by fast liquid chromatography analysis for rapid screening of natural methylglyoxal scavengers directly from herbal medicines: case study of Polygonum cuspidatum.

J. Chromatogr. A. 1286 , 102-10, (2013)

Methylglyoxal (MGO), a very reactive metabolite of glucose, plays a pivotal role in the pathogenesis of several chronic diseases associated with diabetes, and it has been validated as an attractive ta...

 (E/Z)-PolydatinBioassay

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Name: Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL4296184
Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186
Name: Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL4296185
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
Name: Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MI...
Source: ChEMBL
Target: Acinetobacter baumannii
External Id: CHEMBL4296188
Name: Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC...
Source: ChEMBL
Target: Pseudomonas aeruginosa
External Id: CHEMBL4296187
Name: Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); ...
Source: ChEMBL
Target: Cryptococcus neoformans
External Id: CHEMBL4296190
Name: Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB m...
Source: ChEMBL
Target: Candida albicans
External Id: CHEMBL4296189
Name: qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme ...
Source: NCGC
Target: Luciferase [Photinus pyralis]
External Id: FLUC100
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 Synonyms

3,4,5-Tsg
trans-polydatin
MFCD00210592
(E)-Polydatin
Trans-Piceid
Giant knotweed Extract
Piceid
Reservatrol-3-β-mono-D-glucoside
Polydatin
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