Journal of medicinal chemistry

Synthesis of 3-hydroxy-2-and-4-pyridone nucleosides as potential antitumor agents

DT Mao, JS Driscoll, VE Marquez

Index: Mao, David T.; Driscoll, John S.; Marquez, Victor E. Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 160 - 164

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Citation Number: 10

Abstract

The ribo-and arabinofuranosyl nucleosides of antitumor active 2-and 4-pyridones la and 2a were prepared by direct condensation of the silylated bases with either lO-acety~-2, 3, 5-tri- O-benzoyl-~-ribofuranose (4a) or 2, 3, 5-tri-O-benzyl-1-p-nitrobenzoyl-D-arabinofuranose (7) in the presence of trimethylsilyl triflate (Me, SiOTf). In the case of the arabinofuranosyl nucleosides, separation of the a and,/3 anomers was accomplished at the stage of 0- ...