Cationic hydrogenation of benzyl alcohols and arylethylenes using acridane derivatives as hindered NADH models

S Singh, S Chhina, VK Sharma…

Index: Singh, Serjinder; Chhina, Sarbjeet; Sharma, Vijay K.; Sachdev, Satbir S. Journal of the Chemical Society, Chemical Communications, 1982 , # 8 p. 453 - 454

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Citation Number: 40

Abstract

Secondary and tertiary benzyl alcohols and arylethylenes are efficiently reduced by acridane derivatives (1 ) in the presence of trifluoroacetic acid in dichloromethane. ... In steroid biosynthesis, reduction of double bonds usually involves1 protonation and reduction of the incipient carbenium ion catalysed by enzymes possessing NADH as cofactor. We report a reaction in which benzyl alcohols (2) and arylethy- lenes (3) are reduced cleanly at room ...