Tetrahedron letters

Improved method for samarium diiodide induced reductive coupling reactions of acid halides

SM Ruder

Index: Ruder, Suzanne M. Tetrahedron Letters, 1992 , vol. 33, # 19 p. 2621 - 2624

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Citation Number: 51

Abstract

Abstract Acid halides are known to be reductively coupled with aldehydes and ketones in the presence of samarium diiodide to generate α-hydroxy ketones. Low yields coupled product are obtained due to the competitive process of tetrahydrofuran attack on the acid

~77%

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