Carcinogenesis 1983-11-01

Comparative in vivo genotoxicity and acute hepatotoxicity of three 1,2-dihaloethanes.

R D Storer, R B Conolly

Index: Carcinogenesis 4(11) , 1491-4, (1983)

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Abstract

Hepatic DNA damage was demonstrated by alkaline DNA unwinding/hydroxylapatite batch chromatography in male B6C3F1 mice treated with non-necrogenic doses of 1,2-dichloroethane, 1-bromo-2-chloroethane, and 1,2-dibromoethane. Intraperitoneal administration of 0.5 mmol/kg of 1-bromo-2-chloroethane and 1,2-dibromoethane produced similar levels of DNA damage. A 4-fold higher dose of 1,2-dichloroethane (2.0 mmol/kg) was required to produce a comparable effect.