Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1990-11-01

Methyl vinyl sulphone: a new class of Michael-type genotoxin.

T J Warr, J M Parry, R D Callander, J Ashby

Index: Mutat. Res. 245(3) , 191-9, (1990)

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Abstract

Methyl vinyl sulphone (MVS) is a labile, Michael-reactive chemical, similar in structure to acrylamide (AA). Given that acrylamide is a reference mammalian mutagen and a rodent carcinogen, studies were undertaken to evaluate the potential genotoxicity of MVS. In common with AA, MVS was non-mutagenic to Salmonella but active as an aneugen to cultured mammalian cells. It is concluded that vinyl sulphones should be regarded as representative of a new class of genotoxic chemical whose mode of action is probably primarily dependent upon Michael reactivity to proteins.