Several reports in the chemical literature have demonstrated the potentiating effect of an NOH moiety on the antibacterial properties of an arylsulfonamide. For example, N- hydroxybenzenesulfonamide is more potent against Mycobacterium tuberculosis than is benzenesulfonamide'and several N4-acyl-N'-hydroxybenzenesulfonamides are more effective against &hemolytic streptococci in mice than is sulfanilamide itself.'Furthermore, ...
![methyl 3,4-dichloro-9-hydroxy-8-(methoxycarbonylmethyl)-10,10-dioxo-10$l^{6}-thia-7,9-diazabicyclo[4.4.0]deca-1,3,5-triene-8-carboxylate Structure](https://image.chemsrc.com/caspic/040/36110-11-9.png)