e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Aggregative activation in heterocyclic chemistry. Part 5.† Lithiation of pyridine and quinoline with the complex base BuLi· Me 2 N (CH 2) 2 OLi (BuLi· LiDMAE)

P Gros, Y Fort, P Caubère

Index: Gros, Philippe; Fort, Yves; Caubere, Paul Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 24 p. 3597 - 3600

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Citation Number: 70

Abstract

J. Chem. Soc., Perkin Trans. 1, 1997 3597 ... Aggregative activation in heterocyclic chemistry. Part 5.† Lithiation of ... Philippe Gros, Yves Fort and Paul Caubère * ... Laboratoire de Chimie Organique I, Unité Associée au CNRS no 457, Faculté des Sciences, Université Henri Poincaré Nancy-I, BP 239, F-54506 Vandoeuvre-les-Nancy Cédex, France ... It is shown that the complex base BuLi LiDMAE reacts with pyridine to give metallated species which, ...

leucoline Structure

Dimethyl disulfide Structure

Dimethyl disulfide

~56%

2-methylsulfanylquinoline Structure

2-methylsulfany...

2-butylquinoline Structure

2-butylquinoline

Pyridine Structure

N,N-Dimethylformamide Structure

N,N-Dimethylfor...

~40%

2-Pyridinecarboxaldehyde Structure

2-Pyridinecarbo...

leucoline Structure

Benzaldehyde Structure

~45%

2-butylquinoline Structure

2-butylquinoline

2-Quinolinemethanol, a-phenyl- Structure

2-Quinolinemeth...

Pyridine Structure

1-Iodohexane Structure

~43%

2-n-Hexylpyridine Structure

2-n-Hexylpyridine

Pyridine Structure

Acetone Structure

~36%

2-(PYRIDIN-2-YL)PROPAN-2-OL Structure

2-(PYRIDIN-2-YL...

leucoline Structure

Benzophenone Structure

~41%

2-butylquinoline Structure

2-butylquinoline

QUINOLINE-2-YL DIPHENYL METHANOL Structure

QUINOLINE-2-YL ...

Pyridine Structure

~73%

2-Bromopyridine Structure

2-Bromopyridine

leucoline Structure

methyl iodide Structure

~30%

2-ethylquinoline Structure

2-ethylquinoline

2-butylquinoline Structure

2-butylquinoline

leucoline Structure

Chlorotrimethylsilane Structure

Chlorotrimethyl...

~25%

2-butylquinoline Structure

2-butylquinoline

2-trimethylsilanyl-quinoline Structure

2-trimethylsila...

leucoline Structure

Dimethyl disulfide Structure

Dimethyl disulfide

~1%

2-methylsulfanylquinoline Structure

2-methylsulfany...

2-butylquinoline Structure

2-butylquinoline

leucoline Structure

Benzaldehyde Structure

~1%

2-butylquinoline Structure

2-butylquinoline

2-Quinolinemethanol, a-phenyl- Structure

2-Quinolinemeth...

leucoline Structure

n-Butyllithium Structure

~31%

2-butylquinoline Structure

2-butylquinoline

2-trimethylsilanyl-quinoline Structure

2-trimethylsila...

leucoline Structure

Benzophenone Structure

~13%

2-butylquinoline Structure

2-butylquinoline

QUINOLINE-2-YL DIPHENYL METHANOL Structure

QUINOLINE-2-YL ...

leucoline Structure

methyl iodide Structure

~3%

2-ethylquinoline Structure

2-ethylquinoline

2-butylquinoline Structure

2-butylquinoline

Pyridine Structure

1N1&VR Structure

~65%

2-Benzoylpyridine Structure

2-Benzoylpyridine

Pyridine Structure

Dimethyl disulfide Structure

Dimethyl disulfide

~82%

2-Methylthio pyridine Structure

2-Methylthio py...

Pyridine Structure

Chlorotrimethylsilane Structure

Chlorotrimethyl...

~80%

2-(Trimethylsilyl)pyridine Structure

2-(Trimethylsil...

Simple syntheses of aryl alkyl thioethers and of aromatic th...

[Testaferri, L.; Tiecco, M.; Tingoli, M.; Chianelli, D.; Montanucci, M. Synthesis, 1983 , # 9 p. 751 - 755]