Xenobiotica 1986-07-01

Mercapturic acid formation in the marmoset (Callithrix jacchus).

B E Hall, S P James

Index: Xenobiotica 16(7) , 609-14, (1986)

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Abstract

Benzylmercapturic acid is a major metabolite of [methylene-14C]benzyl chloride in the marmoset, as in the rat. The excretion of the minor metabolites benzylmercapturic acid sulphoxide and benzylcysteine accounted for a greater proportion of the dose than in the rat. Excretion of hippuric acid as a metabolite of benzyl chloride was variable in the marmoset. Acetylation of S-benzyl- and S-pentyl-L-cysteine to the corresponding mercapturic acids was extensive in the marmoset. Trace amounts of the sulphoxides of these acids were also excreted.