Acta poloniae pharmaceutica 1996-01-01

Synthesis and CNS activity of new 1-alkyl-2-aryl-7-hydroxy-5(1H)oxo-imidazo[1,2-a]pyrymidines.

D Matosiuk, T Tkaczyński, J Stefańczyk

Index: Acta Pol. Pharm. 53(3) , 209-12, (1996)

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Abstract

Cyclocondensation of 1,5-disubstituted 2-aminoimidazolines with diethyl malonate in the presence of sodium methanolate leading to imidazol[1,2-alpyrimidine-5,7-dion system is presented. Prevailing of 7-hydroxy-5(1H)oxo form between three possible tautomers is discussed based on spectral data. CNS activity of nine compounds is evaluated.