Nucleosides & nucleotides 1998-07-01

Synthesis, antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 2: Adenosine and uridine analogues.

M I Nieto, J M Blanco, O Caamaño, F Fernández, X García-Mera, J Balzarini, E Padalko, J Neyts, E De Clercq

Index: Nucleosides Nucleotides 17(7) , 1255-66, (1998)

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Abstract

Six new carbocyclic nucleosides were prepared by mounting a purine (compounds 5-7), 8-azapurine (compounds 9 and 10) or pyrimidine (compound 13) base on the amino group of (1R,cis)-3-(aminomethyl)-1,2,2-trimethylcyclopentylmethanol (2). The antiviral activity of compounds 5-7, 10 and 13, and their cytostatic activity, were evaluated. At subtoxic concentrations, the compounds showed no or marginal antiviral activity. Compound 5 showed moderate inhibition on tumor cell proliferation.