Archives of Pharmacal Research 2007-07-01

Cephalosporolides H and I, Two Novel Lactones from a Marine-Derived Fungus, Penicillium sp.

Xiang Li, Yanhua Yao, Yinan Zheng, Isabel Sattler, Wenhan Lin

Index: Arch. Pharm. Res. 30(7) , 812-5, (2007)

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Abstract

Two novel lactones, Cephalosporolides H (1) and 1 (2), were isolated from the lyophilized culture broth of the marine-derived fungus, Penicillium sp. The structures were elucidated on the basis of extensive 1D- and 2D-NMR, as well as HRESI-MS spectroscopic analyses. The relative stereochemistries of the compounds were assessed by comparison of the NOESY analysis and spectral data with those in the literature.