Journal of the American Chemical Society

Palladium-Catalyzed Cyclization of. omega.-Haloallenes. A New General Route to Common, Medium, and Large Ring Compounds via Cyclic Carbopalladation

S Ma, E Negishi

Index: Ma, Shengming; Negishi, Ei-Ichi Journal of the American Chemical Society, 1995 , vol. 117, # 23 p. 6345 - 6354

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Citation Number: 152

Abstract

Abstract: A series of w-haloallenes (4-32) as well as related w-haloalkenes (41-45) were prepared through the application of known procedures. Their cyclization in the presence of a catalytic amount of ClzPd (PPh3) 2, a base, eg, KzC03, and other appropriate reagents was investigated mostly under two sets of conditions (conditions I and II). The results summarized in Table 1 reveal the following:(1) The Pd-catalyzed cyclization reaction of w-haloallenes ...