Organic Letters 2009-01-15

Stable preformed chiral palladium catalysts for the one-pot asymmetric reductive amination of ketones.

Laura Rubio-Pérez, F Javier Pérez-Flores, Pankaj Sharma, Luis Velasco, Armando Cabrera

Index: Org. Lett. 11 , 265-268, (2009)

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Abstract

The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (<99% ee), is reported.

Structure	Name/CAS No.	Molecular Formula	Articles
	Palladium, [1,1'-(1R)-[1,1'-binaphthalene]-2,2'-diylbis[1,1-diphenylphosphine-κP]]dibromo-, (SP-4-2) CAS:923987-15-9	C₄₄H₃₂Br₂P₂Pd
	dibromo(2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)palladium(II) CAS:366488-99-5	C₄₄H₃₂Br₂P₂Pd

Stable preformed chiral palladium catalysts for the one-pot asymmetric reductive amination of ketones.

Abstract

Related Compounds