Journal of the American Chemical Society 2014-12-24

One-step synthesis of saturated spirocyclic N-heterocycles with stannyl amine protocol (SnAP) reagents and ketones.

Woon-Yew Siau, Jeffrey W Bode

Index: J. Am. Chem. Soc. 136(51) , 17726-9, (2014)

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Abstract

The combination of cyclic ketones and stannyl amine protocol (SnAP) reagents affords saturated, spirocyclic N-heterocycles under operationally simple reaction conditions. The resulting, N-unprotected spirocyclic amines are in great demand as scaffolds for drug discovery and development. The union of SnAP reagents and acyclic trifluoromethylketones yields α-CF3 morpholines and piperazines.