Bioorganic & Medicinal Chemistry Letters 2013-03-15

Stability studies of ascorbic acid 2-glucoside in cosmetic lotion using surface response methodology.

Wen-Ying Huang, Pei-Chi Lee, Ling-Kuei Huang, Li-Ping Lu, Wayne C Liao

Index: Bioorg. Med. Chem. Lett. 23(6) , 1583-7, (2013)

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Abstract

Ascorbic acid 2-glucoside (AA-2G) has been widely used in cream and lotion types of cosmetic products. Thus, the degradation of AA-2G caused by the temperature change and pH variation was very critical for determining the bio-functionality of cosmetics. Response surface methodology (RSM) was introduced to study the influence of temperature and pH on the stability of AA-2G. The optimal condition of retaining AA-2G with the highest stability was determined to be 55.3°C and pH 6.4. The antioxidative activities of AA-2G including DPPH and ABTS free radical scavenging activities, metal chelating activity, and reducing ability were also determined. AA-2G was a good ascorbic acid derivative which could be used in cosmetic products as an active ingredient.Copyright © 2013 Elsevier Ltd. All rights reserved.