Peroxygenase and oxidase activities of dehaloperoxidase-hemoglobin from Amphitrite ornata

DA Barrios, J D'Antonio, NL McCombs…

Index: Barrios, David A.; D'Antonio, Jennifer; McCombs, Nikolette L.; Zhao, Jing; Franzen, Stefan; Schmidt, Andreas C.; Sombers, Leslie A.; Ghiladi, Reza A. Journal of the American Chemical Society, 2014 , vol. 136, # 22 p. 7914 - 7925

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Citation Number: 10

Abstract

The marine globin dehaloperoxidase-hemoglobin (DHP) from Amphitrite ornata was found to catalyze the H2O2-dependent oxidation of monohaloindoles, a previously unknown class of substrate for DHP. Using 5-Br-indole as a representative substrate, the major monooxygenated products were found to be 5-Br-2-oxindole and 5-Br-3-oxindolenine. Isotope labeling studies confirmed that the oxygen atom incorporated was derived ...