Solvent??Free Microwave??Assisted Efficient Synthesis of 4, 4??Disubstituted 2??Oxazolines

…, A Loupy, A Petit, AL Marrero??Terrero

Index: Garcia-Tellado, Fernando; Loupy, Andre; Petit, Alain; Marrero-Terrero, Alma Leilani European Journal of Organic Chemistry, 2003 , # 22 p. 4387 - 4391

Full Text: HTML

Citation Number: 14

Abstract

Abstract 4, 4-Disubstituted 2-oxazolines have been synthesized by a microwave-promoted solvent-free direct condensation of carboxylic acids and disubstituted β-amino alcohols in good to excellent yields. Zinc oxide is a very good solid support in cases where a Lewis acid is required. The method described herein is a very good, safe, clean, economical, and environmentally friendly alternative to the classical procedures.(© Wiley-VCH Verlag ...