Syntheses of new 3-thiazolyl coumarin derivatives, in vitro α-glucosidase inhibitory activity, and molecular modeling studies

U Salar, M Taha, KM Khan, NH Ismail, S Imran…

Index: Khan; Saify; Ahmed; Saeed; Schick; Kohlbau; Voelter Arzneimittel-Forschung/Drug Research, 2000 , vol. 50, # 10 p. 915 - 924

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Citation Number: 3

Abstract

Abstract 3-Thiazolylcoumarin derivatives 1–14 were synthesized via one-pot two step reactions, and screened for in vitro α-glucosidase inhibitory activity. All compounds showed inhibitory activity in the range of IC 50= 0.12±0.01–16.20±0.23 μM as compared to standard