Bioorganic & Medicinal Chemistry Letters 2008-12-15

Vasodilatation effect of farnesylacetones, active constituents of Sargassum siliquastrum, on the basilar and carotid arteries of rabbits.

Byong-Gon Park, Seong-Chun Kwon, Gab-Man Park, Jungyeob Ham, Woon-Seob Shin, Seokjoon Lee

Index: Bioorg. Med. Chem. Lett. 18(24) , 6324-6, (2008)

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Abstract

Two farnesylacetones, 311 and 312, major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with farnesylacetones 311 and 312 may selectively accelerate cerebral blood flow through dilatation of the basilar artery.