Food and Chemical Toxicology
2011-12-01
Evaluation of the developmental toxicity of leucomalachite green administered orally to rats
Hongping Wan, Shaoping Weng, Lizhen Liang, Qihua Lu, Jianguo He
Index: Food Chem. Toxicol. 49(12) , 3031-7, (2011)
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Abstract
Highlights ► The unmetabolized compound was detected in the plasma of the rat treated with LMG. ► LMG entered the amniotic fluid through the placental barrier. ► LMG at 160mg/kg/day caused embryolethality in rats. ► LMG at 80–160mg/kg/day caused fetal developmental toxicity in rats. ► In this study, the maternal and developmental toxicity NOAEL of LMG was 10mg/kg/day.
Related Compounds
| Structure | Name/CAS No. | Molecular Formula | Articles |
|---|---|---|---|
 |
LEUCOMALACHITE GREEN
CAS:129-73-7 |
C23H26N2 |
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