Food and Chemical Toxicology 2011-12-01

Evaluation of the developmental toxicity of leucomalachite green administered orally to rats

Hongping Wan, Shaoping Weng, Lizhen Liang, Qihua Lu, Jianguo He

文献索引：Food Chem. Toxicol. 49(12) , 3031-7, (2011)

全文：HTML全文

摘要

Highlights ► The unmetabolized compound was detected in the plasma of the rat treated with LMG. ► LMG entered the amniotic fluid through the placental barrier. ► LMG at 160mg/kg/day caused embryolethality in rats. ► LMG at 80–160mg/kg/day caused fetal developmental toxicity in rats. ► In this study, the maternal and developmental toxicity NOAEL of LMG was 10mg/kg/day.