Nucleosides, Nucleotides & Nucleic Acids 2005-01-01

Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer.

A V Silamkoti, P W Allan, A E A Hassan, A T Fowler, E J Sorscher, W B Parker, J A Secrist

Index: Nucleosides Nucleotides Nucleic Acids 24 , 881-885, (2005)

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Abstract

A novel series of 6-methylpurine nucleoside derivatives with substitutions at 5-position have been synthesised These compounds bear a 5'-heterocycle such as triazole or a imidazole with a two carbon chain, and an ether, thio ether or amine. To extend the SAR study of 2-fluoroadenine and 6-methyl purine nucleosides, their corresponding alpha-linker nucleosides with L-xylose and L-lyxose were also synthesized. All of these compounds have been evaluated for their substrate activity with E. coli PNP.