Organic Letters 2012-01-20

Rh(I)-catalyzed asymmetric 1,2-addition to α-diketones with chiral sulfur-alkene hybrid ligands.

Xiangqing Feng, Yanzhao Nie, Jing Yang, Haifeng Du

Index: Org. Lett. 2nd ed., 14 , 624-627, (2012)

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Abstract

This paper describes a Rh(I)-catalyzed highly efficient and enantioselective 1,2-addition of arylboronic acids to α-diketones with the use of a simple sulfur-alkene hybrid ligand. With as low as a 0.1 mol % catalyst loading, a variety of optically active α-hydroxyketones can be furnished in high yields with excellent ee's.© 2012 American Chemical Society