Potential antiarthritic agents. 2. Benzoylacetonitriles and. beta.-aminocinnamonitriles

…, BD Johnson, J Menschik, G Nicolau…

Index: Ridge; Hanifin; Harten; Johnson; Menschik; Nicolau; Sloboda; Watts Journal of Medicinal Chemistry, 1979 , vol. 22, # 11 p. 1385 - 1389

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Citation Number: 51

Abstract

Benzoylacetonitrile and P-aminocinnamonitrile are shown to possess potent antiinflammatory activity in the rat adjuvant arthritis model. In a series of phenyl-substituted analogues, only 0-, m-, and p-fluorobenzoylacetonitrile and m-and p-fluoro-6- aminocinnamonitrile retained activity. Additionally, P-amino-2-and P-amino-3- thiopheneacrylonitrile and 0-oxo-2-and P-oxo-3-thiophenepropionitrile exhibited similar ...

Design, synthesis, and evaluation of 2-aryl-7-(3′, 4′-dialko...

[Kim, Ikyon; Song, Jong Hwan; Park, Chang Min; Jeong, Joon Won; Kim, Hyung Rae; Ha, Jin Ryul; No, Zaesung; Hyun, Young-Lan; Cho, Young Sik; Sook Kang, Nam; Jeon, Dong Ju Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 922 - 926]

Synthesis and biological effects of a new series of 2-amino-...

[Baraldi, Pier Giovanni; Zaid, Abdel Naser; Lampronti, Ilaria; Fruttarolo, Francesca; Pavani, Maria Giovanna; Tabrizi, Mojgan Aghazadhe; Shryock, John C.; Leung, Edward; Romagnoli, Romeo Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 17 p. 1953 - 1957]