Potential antiarthritic agents. 2. Benzoylacetonitriles and. beta.-aminocinnamonitriles

…, BD Johnson, J Menschik, G Nicolau…

文献索引：Ridge; Hanifin; Harten; Johnson; Menschik; Nicolau; Sloboda; Watts Journal of Medicinal Chemistry, 1979 , vol. 22, # 11 p. 1385 - 1389

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被引用次数: 51

摘要

Benzoylacetonitrile and P-aminocinnamonitrile are shown to possess potent antiinflammatory activity in the rat adjuvant arthritis model. In a series of phenyl-substituted analogues, only 0-, m-, and p-fluorobenzoylacetonitrile and m-and p-fluoro-6- aminocinnamonitrile retained activity. Additionally, P-amino-2-and P-amino-3- thiopheneacrylonitrile and 0-oxo-2-and P-oxo-3-thiophenepropionitrile exhibited similar ...