Chemical Communications 2013-05-14

Internal Lewis acid assisted ureas: tunable hydrogen bond donor catalysts.

David M Nickerson, Veronica V Angeles, Tyler J Auvil, Sonia S So, Anita E Mattson

Index: Chem. Commun. (Camb.) 49 , 4289-4291, (2013)

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Abstract

The strategic incorporation of internal Lewis acids onto urea scaffolds gives rise to a family of tunable hydrogen bond donor catalysts. The nature of the Lewis acid and associated ligands affects the urea polarization, acidity, and activity in reactions of nitrocyclopropane carboxylates and nitrodiazoesters.