Journal of Organic Chemistry 2014-06-06

Urea-catalyzed N-H insertion-arylation reactions of nitrodiazoesters.

Sonia S So, Shameema Oottikkal, Jovica D Badjić, Christopher M Hadad, Anita E Mattson

Index: J. Org. Chem. 79(11) , 4832-42, (2014)

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Abstract

The power of hydrogen-bond donor catalysis has been harnessed to elicit and control carbene-like reactivity from nitrodiazoesters. Specifically, select ureas have been identified as effective catalysts for N-H insertion and multicomponent coupling reactions of nitrodiazoesters, anilines, and aromatic nucleophiles, thereby preparing a variety of α-aryl glycines in high yield. Experimental and computational studies designed to probe the plausible reaction pathways suggest that difluoroboronate ureas are particularly well-suited to catalyze reactions of nitrodiazoesters with a range of anilines through a polar reaction pathway. Urea-facilitated loss of nitrite followed by addition of a nucleophile conceivably generates the observed aryl glycine products.